Article
A large fraction of trisomy 12, 17p-, and 11q- CLL cases carry unidentified microdeletions of miR-15a/16-1.
Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2022
Pepe Felice, Rassenti Laura Z, Pekarsky Yuri, Labanowska Jadwiga, Nakamura Tatsuya, Nigita Giovanni, Kipps Thomas J, Balatti Veronica, Croce Carlo M
Abstract excerpt
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia and is characterized by chromosomal aberrations including 13q, 11q, and 17p deletions and a trisomy of chromosome 12 (T12). 13q deletions are often associated with 11q and 17p deletions in aggressive cases. Conversely, T12 CLLs show a variable prognosis, and association with 13q deletions is uncommon. The miR-15a/16-1 cluster is the functional...
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