Integrative genomics analyses reveal molecularly distinct subgroups of B-cell chronic lymphocytic leukemia patients with 13q14 deletion.

doi:10.1158/1078-0432.CCR-10-0151

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Article

Integrative genomics analyses reveal molecularly distinct subgroups of B-cell chronic lymphocytic leukemia patients with 13q14 deletion.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2010

Mosca Laura, Fabris Sonia, Lionetti Marta, Todoerti Katia, Agnelli Luca, Morabito Fortunato, Cutrona Giovanna, Andronache Adrian, Matis Serena, Ferrari Francesco, Gentile Massimo, Spriano Mauro, Callea Vincenzo, Festini Gianluca, Molica Stefano, Deliliers Giorgio Lambertenghi, Bicciato Silvio, Ferrarini Manlio, Neri Antonino

Abstract excerpt

PURPOSE: Chromosome 13q14 deletion occurs in a substantial number of chronic lymphocytic leukemia (CLL) patients and it is believed to play a pathogenetic role. The exact mechanisms involved in this lesion have not yet been fully elucidated because of its heterogeneity and the imprecise knowledge of the implicated genes. This study was addressed to further contribute to the molecular definition of this lesion in...

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PMID: 20947517
DOI: 10.1158/1078-0432.CCR-10-0151

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