Generation of class I MHC-restricted T-T hybridomas.

Article

Generation of class I MHC-restricted T-T hybridomas.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 1990

Rock K L, Rothstein L, Gamble S

Abstract excerpt

In this report we describe a system for the generation of functional, class I MHC-restricted, T-T hybridomas. The BW5147 cell line was transfected with the CD8 gene. BW5147 transfectants were obtained that stably expressed CD8 and this expression was maintained after somatic cell hybridization wi...

Topics

Animals
Antigens, Differentiation, T-Lymphocyte
CD8 Antigens
Histocompatibility Antigens Class I
Hybridomas
Lymphokines
Mice
Mice, Inbred Strains
Phenotype
T-Lymphocytes
Transfection

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