Article
Characterization of B16 melanoma-specific cytotoxic T lymphocytes.
Cancer immunology, immunotherapy : CII - 1 Dec 1998
Harada M, Tamada K, Abe K, Li T, Onoe Y, Tada H, Tatsugami K, Ando T, Kimura G, Nomoto K
Abstract excerpt
A B16 melanoma-specific CD8+ T cell line (AB1) was established from the spleen cells of C57BL/6 mice cured of B16 melanoma with interleukin (IL)-12 treatment. The AB1 line exclusively used T cell receptor Vbeta11. The AB1 cells exhibited a cytolytic activity against both syngeneic B16 melanoma and allogeneic P815 mastocytoma, whereas a cold inhibition assay revealed specificity of the AB1 cells against B16...
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