Article
MHC class II-transfected tumor cells directly present antigen to tumor-specific CD4+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1998
Armstrong T D, Clements V K, Ostrand-Rosenberg S
Abstract excerpt
We have developed and shown to be efficacious an immunotherapeutic strategy to enhance the generation of tumor-specific CD4+ T helper lymphocytes. The approach uses autologous tumor cells genetically modified to express syngeneic MHC class II genes as cell-based immunogens and is based on the hyp...
Topics
- Animals
- Antigen Presentation
- Antigen-Presenting Cells
- CD4-Positive T-Lymphocytes
- Cell Membrane
- Female
- Gene Expression Regulation, Neoplastic
- Genotype
- Histocompatibility Antigens Class II
- Intracellular Fluid
- Lymphocyte Activation
- Mice
- Mice, Inbred A
- Mice, Inbred C57BL
- Muramidase
- Peptide Fragments
- Radiation Chimera
- Sarcoma, Experimental