Article
Voxel-based morphometry in frontotemporal lobar degeneration with ubiquitin-positive inclusions with and without progranulin mutations.
Archives of neurology - 1 Mar 2007
Whitwell Jennifer L, Jack Clifford R, Baker Matthew, Rademakers Rosa, Adamson Jennifer, Boeve Bradley F, Knopman David S, Parisi Joseph F, Petersen Ronald C, Dickson Dennis W, Hutton Michael L, Josephs Keith A
Abstract excerpt
BACKGROUND: Mutations in the progranulin gene (PGRN) have recently been identified as a cause of frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) in some families. OBJECTIVE: To determine whether there is a difference in the patterns of atrophy in FTLD-U cases with and without PGRN mutations. DESIGN: Case-control study. SETTING: Brain bank of a tertiary care medical center. Patients...
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