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Article

Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations.

Journal of neuropathology and experimental neurology - 1 Feb 2007

Josephs Keith A, Ahmed Zeshan, Katsuse Omi, Parisi Joseph F, Boeve Bradley F, Knopman David S, Petersen Ronald C, Davies Peter, Duara Ranjan, Graff-Radford Neill R, Uitti Ryan J, Rademakers Rosa, Adamson Jennifer, Baker Matthew, Hutton Michael L, Dickson Dennis W

Abstract excerpt

Frontotemporal lobar degeneration is heterogeneous; cases with tau- and synuclein-negative, ubiquitin-positive neuronal inclusions are the most common, and some have mutations in the gene for progranulin (PGRN). The purpose of this study was to determine whether there were distinctive clinical and neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with PGRN mutations....

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PMID: 17278999
DOI: 10.1097/nen.0b013e31803020cf

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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