Article
Lack of germline PALB2 mutations in melanoma-prone families with CDKN2A mutations and pancreatic cancer.
Familial cancer - 1 Sept 2011
Yang Xiaohong R, Jessop Lea, Myers Timothy, Amundadottir Laufey, Pfeiffer Ruth M, Wheeler William, Pike Kristen M, Yuenger Jeff, Burdett Laurie, Yeager Meredith, Chanock Stephen J, Tucker Margaret A, Goldstein Alisa M
Abstract excerpt
The presence of pancreatic cancer (PC) in melanoma-prone families has been consistently associated with an increased frequency of CDKN2A mutations, the major high-risk susceptibility gene identified for melanoma. However, the precise relationship between CDKN2A, melanoma and PC remains unknown. We evaluated a recently identified PC susceptibility gene PALB2 using both sequencing and tagging to determine whether...
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