Article
Nucleolin, a shuttle protein promoting infection of human monocytes by Francisella tularensis.
PloS one - 1 Dec 2010
Barel Monique, Meibom Karin, Charbit Alain
Abstract excerpt
BACKGROUND: Francisella tularensis is a highly virulent facultative intracellular bacterium, disseminating in vivo mainly within host mononuclear phagocytes. After entry into macrophages, F. tularensis initially resides in a phagosomal compartment, whose maturation is then arrested. Bacteria escape rapidly into the cytoplasm, where they replicate freely. We recently demonstrated that nucleolin, an eukaryotic...
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