Article
Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling.
Journal of leukocyte biology - 1 Feb 2010
Cole Leah E, Laird Michelle H W, Seekatz Anna, Santiago Araceli, Jiang Zhaozhao, Barry Eileen, Shirey Kari Ann, Fitzgerald Katherine A, Vogel Stefanie N
Abstract excerpt
TLR2 plays a central role in the activation of innate immunity in response to Ft, the causative agent of tularemia. We reported previously that Ft LVS elicited strong, dose-dependent NF-kappaB reporter activity in TLR2-expressing human embryo kidney 293 T cells and that Ft LVS-induced murine macrophage proinflammatory cytokine gene and protein expression is TLR2-dependent. We demonstrated further that Ft can...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.