Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytosolic clearance of replication-deficient mutants reveals Francisella tularensis interactions with the autophagic pathway.

Autophagy - 1 Sept 2012

Chong Audrey, Wehrly Tara D, Child Robert, Hansen Bryan, Hwang Seungmin, Virgin Herbert W, Celli Jean

Abstract excerpt

Cytosolic bacterial pathogens must evade intracellular innate immune recognition and clearance systems such as autophagy to ensure their survival and proliferation. The intracellular cycle of the bacterium Francisella tularensis is characterized by rapid phagosomal escape followed by extensive proliferation in the macrophage cytoplasm. Cytosolic replication, but not phagosomal escape, requires the locus FTT0369c,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endosomes
Share to Francisella tularensis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Space

Share to Microbial Viability

Share to Phagosomes

Share to Sequestosome-1 Protein

Share to Ubiquitin

Share to Vacuoles

Source

Open in PubMed Open full text

Identifiers

PMID: 22863802
DOI: 10.4161/auto.20808
PMCID: PMC3442881

Genes

SQSTM1
ATG5
LAMP1
NBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytosolic clearance of replication-deficient mutants reveals Francisella tularensis interactions with the autophagic pathway.PMID 22863802Read ↗

A Francisella tularensis pathogenicity island protein essential for bacterial proliferation within the host cell cytosol.Semantic proximity Read ↗

Host Factors Required for Modulation of Phagosome Biogenesis and Proliferation of Francisella tularensis within the CytosolSemantic proximity Read ↗

Molecular bases of proliferation of Francisella tularensis in arthropod vectorsSemantic proximity Read ↗

Acquisition of the vacuolar ATPase proton pump and phagosome acidification are essential for escape of Francisella tularensis into the macrophage cytosol.Semantic proximity Read ↗

The Francisella tularensis pathogenicity island protein IglC and its regulator MglA are essential for modulating phagosome biogenesis and subsequent bacterial escape into the cytoplasm.Semantic proximity Read ↗

Exploitation of Host Cell Biology and Evasion of Immunity by Francisella TularensisSemantic proximity Read ↗

Identification of mechanisms for attenuation of the FSC043 mutant of Francisella tularensis SCHU S4.Semantic proximity Read ↗

Cell biology and molecular ecology of<i>Francisella tularensis</i>Semantic proximity Read ↗

Manipulation of Host Cell Organelles by Intracellular PathogensSemantic proximity Read ↗

Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC genes results in attenuation for growth in human macrophages and in vivo virulence in mice and reveals a unique phenotype for pdpC.Semantic proximity Read ↗

Uncovering the components of the Francisella tularensis virulence stealth strategy.Semantic proximity Read ↗

Identification of transposon insertion mutants of Francisella tularensis tularensis strain Schu S4 deficient in intracellular replication in the hepatic cell line HepG2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.