Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of mechanisms for attenuation of the FSC043 mutant of Francisella tularensis SCHU S4.

Infection and immunity - 1 Sept 2014

Lindgren Marie, Tancred Linda, Golovliov Igor, Conlan Wayne, Twine Susan M, Sjöstedt Anders

Abstract excerpt

Previously, we identified a spontaneous, essentially avirulent mutant, FSC043, of the highly virulent strain SCHU S4 of Francisella tularensis subsp. tularensis. We have now characterized the phenotype of the mutant and the mechanisms of its attenuation in more detail. Genetic and proteomic analyses revealed that the pdpE gene and most of the pdpC gene were very markedly downregulated and, as previously...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down-Regulation
Share to Francisella tularensis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages

Share to Mice, Inbred C57BL

Share to Phagosomes

Share to Proteomics

Share to Tularemia

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 24935978
DOI: 10.1128/IAI.01406-13
PMCID: PMC4187832

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of mechanisms for attenuation of the FSC043 mutant of Francisella tularensis SCHU S4.PMID 24935978Read ↗

Uncovering the components of the Francisella tularensis virulence stealth strategy.Semantic proximity Read ↗

The Francisella tularensis LVS ΔpdpC mutant exhibits a unique phenotype during intracellular infection.Semantic proximity Read ↗

Disruption of Francisella tularensis Schu S4 iglI, iglJ, and pdpC genes results in attenuation for growth in human macrophages and in vivo virulence in mice and reveals a unique phenotype for pdpC.Semantic proximity Read ↗

A mutant of Francisella tularensis strain SCHU S4 lacking the ability to express a 58-kilodalton protein is attenuated for virulence and is an effective live vaccine.Semantic proximity Read ↗

Intracellular biology and virulence determinants of<i>Francisella tularensis</i>revealed by transcriptional profiling inside macrophagesSemantic proximity Read ↗

IglG and IglI of the Francisella Pathogenicity Island Are Important Virulence Determinants of Francisella tularensis LVSSemantic proximity Read ↗

Molecular bases of proliferation of Francisella tularensis in arthropod vectorsSemantic proximity Read ↗

The Francisella pathogenicity island protein PdpD is required for full virulence and associates with homologues of the type VI secretion system.Semantic proximity Read ↗

Cell biology and molecular ecology of<i>Francisella tularensis</i>Semantic proximity Read ↗

Francisella tularensis Schu S4 O-antigen and capsule biosynthesis gene mutants induce early cell death in human macrophages.Semantic proximity Read ↗

A Francisella tularensis pathogenicity island protein essential for bacterial proliferation within the host cell cytosol.Semantic proximity Read ↗

Identification of genes contributing to the virulence of Francisella tularensis SCHU S4 in a mouse intradermal infection model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.