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The fatty acid oleate is required for innate immune activation and pathogen defense in Caenorhabditis elegans

17 Jun 2019

Abstract excerpt

Fatty acids affect a number of physiological processes, in addition to forming the building blocks of membranes and body fat stores. In this study, we uncover a role for the monounsaturated fatty acid oleate in the innate immune response of the nematode Caenorhabditis elegans. From an RNAi screen for regulators of innate immune defense genes, we identified the two stearoyl-coenzyme A desaturases that synthesize...

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PMID: 31206555
DOI: 10.1371/journal.ppat.1007893

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