Article
The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium.
Disease models & mechanisms - 1 Jan 2012
Chang Pishan, Orabi Benoit, Deranieh Rania M, Dham Manik, Hoeller Oliver, Shimshoni Jakob A, Yagen Boris, Bialer Meir, Greenberg Miriam L, Walker Matthew C, Williams Robin S B
Abstract excerpt
Valproic acid (VPA) is the most widely prescribed epilepsy treatment worldwide, but its mechanism of action remains unclear. Our previous work identified a previously unknown effect of VPA in reducing phosphoinositide production in the simple model Dictyostelium followed by the transfer of data to a mammalian synaptic release model. In our current study, we show that the reduction in phosphoinositide [PtdInsP...
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