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Article

Unique Mechanism of Action of the Thiourea Drug Isoxyl on Mycobacterium tuberculosis

1 Dec 2003

Abstract excerpt

The thiourea isoxyl (thiocarlide; 4,4'-diisoamyloxydiphenylthiourea) is known to be an effective anti-tuberculosis drug, active against a range of multidrug-resistant strains of Mycobacterium tuberculosis and has been used clinically. Little was known of its mode of action. We now demonstrate that isoxyl results in a dose-dependent decrease in the synthesis of oleic and, consequently, tuberculostearic acid in M....

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PMID: 14559907
DOI: 10.1074/jbc.m311209200

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