Article
T-cell-epitope mapping of the idiotypic monoclonal IgG heavy and light chains in multiple myeloma.
International journal of cancer - 1 Mar 1999
Fagerberg J, Yi Q, Gigliotti D, Harmenberg U, Rudén U, Persson B, Osterborg A, Mellstedt H
Abstract excerpt
The idiotypic structures of the myeloma protein might be regarded as tumor-specific antigens. The present study was designed to map T-cell epitopes of the idiotypic myeloma protein to prove the existence of naturally occurring major-histocompatibility-complex-dependent idiotype (peptide)-specific T cells in multiple myeloma. The fine specificity of idiotype-reactive, interferon-gamma-producing blood T cells of a...
Topics
- Aged
- Amino Acid Sequence
- Antibodies, Monoclonal
- Base Sequence
- Epitopes
- Humans
- Immunoglobulin G
- Immunoglobulin Heavy Chains
- Immunoglobulin Idiotypes
- Immunoglobulin Light Chains
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains
- Major Histocompatibility Complex