Article
An inducer of VGF protects cells against ER stress-induced cell death and prolongs survival in the mutant SOD1 animal models of familial ALS.
PloS one - 9 Dec 2010
Shimazawa Masamitsu, Tanaka Hirotaka, Ito Yasushi, Morimoto Nobutaka, Tsuruma Kazuhiro, Kadokura Michinori, Tamura Shigeki, Inoue Teruyoshi, Yamada Mitsunori, Takahashi Hitoshi, Warita Hitoshi, Aoki Masashi, Hara Hideaki
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is the most frequent adult-onset motor neuron disease, and recent evidence has suggested that endoplasmic reticulum (ER) stress signaling is involved in the pathogenesis of ALS. Here we identified a small molecule, SUN N8075, which has a marked protective effec...
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