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Article

Increased ER stress during motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis

30 Nov 2007

Abstract excerpt

The endoplasmic reticulum (ER), which plays important roles in apoptosis, is susceptible to oxidative stress. ER stress is also thought to be involved in the pathogenesis of neurodegenerative diseases. In this study, we investigated whether ER stress is involved in the pathogenesis of amyotrophic lateral sclerosis (ALS) using the anterior part of the lumbar spinal cord of transgenic mice carrying a mutation...

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PMID: 17672929
DOI: 10.1179/016164107x229803

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