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SIGMAR1 targets AMPK/ULK1 pathway to inhibit SH-SY5Y cell apoptosis by regulating endoplasmic reticulum stress and autophagy.

Functional & integrative genomics - 7 Aug 2024

Kong Min, Chen Zhiheng, Lin Zhiqiang, Yin Ping, Zhao Qin

Abstract excerpt

Distal hereditary motor neuropathy (dHMN) is a progressive neurological disease characterized by distal limb muscle weakness and amyotrophy. Sigma 1 receptor (σ1R), a gene product of SIGMAR1, mutations have been reported to induce dHMN, but its mechanism remains unknown. This study aims to explore the effect of C238T and 31_50del mutations in σ1R on neuronal SH-SY5Y cell functions. The SH-SY5Y cells that...

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PMID: 39107544
DOI: 10.1007/s10142-024-01414-y

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