Article

CDNF rescues motor neurons in three animal models of ALS by targeting ER stress

2020-05-06

Abstract excerpt

The role of chronic endoplasmic reticulum (ER) stress in the pathophysiology of Amyotrophic lateral sclerosis (ALS), as well as a potential drug target, has received increasing attention. Here, we investigated the mode of action and therapeutic effect of the ER resident protein cerebral dopamine neurotrophic factor (CDNF) in preclinical models of ALS harboring different genetic mutations. We identify that intracer...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2a0db5e1-5873-5ede-9cc9-88d291adf19a
DOI: 10.1101/2020.05.05.078618

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CDNF rescues motor neurons in three animal models of ALS by targeting ER stressDOI 10.1101/2020.05.05.078618Read

Stress signaling from the endoplasmic reticulum: A central player in the pathogenesis of amyotrophic lateral sclerosisSemantic proximity Read

Analyzing ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targetsSemantic proximity Read

Kaempferol enhances ER-mitochondria coupling and protects motor neurons from ER stress and mitochondrial dysfunction in C9ORF72- ALSSemantic proximity Read

Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTDSemantic proximity Read

Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neuronsSemantic proximity Read

ERp57 is protective against mutant SOD1-induced cellular pathology in amyotrophic lateral sclerosis.Semantic proximity Read

Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neuronsSemantic proximity Read

Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS/FTDSemantic proximity Read

An inducer of VGF protects cells against ER stress-induced cell death and prolongs survival in the mutant SOD1 animal models of familial ALS.Semantic proximity Read

Retrospective Study of the Physiological and Molecular Features of the S-FUS (1-359) Mouse Transgenic Model with an ALS-like Phenotype: Lifespan, Body Weight Dynamics, Movement Disorders, and Dysregulation of the Dopaminergic System.Semantic proximity Read

ER Stress and UPR in Familial Amyotrophic Lateral SclerosisSemantic proximity Read

Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatment.Semantic proximity Read