Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The ALS-inducing factors, TDP43A315T and SOD1G93A, directly affect and sensitize sensory neurons to stress.

Scientific reports - 8 Nov 2018

Vaughan Sydney K, Sutherland Natalia M, Zhang Sihui, Hatzipetros Theo, Vieira Fernando, Valdez Gregorio

Abstract excerpt

There is increased recognition that sensory neurons located in dorsal root ganglia (DRG) are affected in amyotrophic lateral sclerosis (ALS). However, it remains unknown whether ALS-inducing factors, other than mutant superoxide dismutase 1 (SOD1G93A), directly affect sensory neurons. Here, we examined the effect of mutant TAR DNA-binding protein 1 (TDP43A315T) on sensory neurons in culture and in vivo. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to eIF-2 Kinase

Share to Neurites

Share to Sensory Receptor Cells

Share to Superoxide Dismutase-1

Share to Vincristine

Source

Open in PubMed Open full text

Identifiers

PMID: 30410094
DOI: 10.1038/s41598-018-34510-8
PMCID: PMC6224462

Genes

ATF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The ALS-inducing factors, TDP43A315T and SOD1G93A, directly affect and sensitize sensory neurons to stress.PMID 30410094Read ↗

Specific vulnerability of iPSC-derived motor neurons with TDP-43 gene mutation to oxidative stress.Semantic proximity Read ↗

Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations.Semantic proximity Read ↗

ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor NeuronsSemantic proximity Read ↗

Mutant SOD1 accumulation in sensory neurons does not associate with endoplasmic reticulum stress features: Implications for differential vulnerability of sensory and motor neurons to SOD1 toxicity.Semantic proximity Read ↗

Stress signaling from the endoplasmic reticulum: A central player in the pathogenesis of amyotrophic lateral sclerosisSemantic proximity Read ↗

An inducer of VGF protects cells against ER stress-induced cell death and prolongs survival in the mutant SOD1 animal models of familial ALS.Semantic proximity Read ↗

Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase.Semantic proximity Read ↗

Mitochondrial dysfunction heightens the integrated stress response to drive ALS pathogenesisSemantic proximity Read ↗

AAV-based delivery of RNAi targeting ataxin-2 improves survival and pathology in TDP-43 miceSemantic proximity Read ↗

ALS-Linked Mutant SOD1 Associates with TIA-1 and Alters Stress Granule Dynamics.Semantic proximity Read ↗

ALS mouse model SOD1G93Adisplays early pathology of sensory small fibers associated to accumulation of a neurotoxic splice variant of peripherinSemantic proximity Read ↗

Sensory involvement in the SOD1-G93A mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.