Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discovery of Vinyl Sulfones as a Novel Class of Neuroprotective Agents toward Parkinson’s Disease Therapy

27 Jan 2014

Abstract excerpt

Although the etiology of Parkinson's disease (PD) remains elusive, recent studies suggest that oxidative stress contributes to the cascade leading to dopaminergic (DAergic) neurodegeneration. The Nrf2 signaling is the main pathway responsible for cellular defense system against oxidative stress. Nrf2 is a transcription factor that regulates environmental stress response by inducing expression of antioxidant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genomics, phytochemicals, and oxidative stress
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24467268
DOI: 10.1021/jm401788m

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discovery of Vinyl Sulfones as a Novel Class of Neuroprotective Agents toward Parkinson’s Disease TherapyPMID 24467268Read ↗

Activation of Nrf2 Neuroprotective Pathways for Treatment of Parkinson’s Disease: A State of Art ReviewSemantic proximity Read ↗

Evaluation of potential neuroprotective effects of Vanillin against MPP+/MPTP-induced dysregulation of dopaminergic regulatory mechanisms in SH-SY5Y cells and a mouse model of Parkinson's diseaseSemantic proximity Read ↗

Neuroprotective Effect of the Marine-Derived Compound 11-Dehydrosinulariolide through DJ-1-Related Pathway in In Vitro and In Vivo Models of Parkinson’s DiseaseSemantic proximity Read ↗

Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's DiseaseSemantic proximity Read ↗

Evaluation of potential neuroprotective effects of Vanillin against MPP+/MPTP-induced dysregulation of dopaminergic regulatory mechanisms in SH-SY5Y cells and Parkinson's disease mice modelSemantic proximity Read ↗

The Nrf2-ARE Pathway: A Valuable Therapeutic Target for the Treatment of Neurodegenerative DiseasesSemantic proximity Read ↗

Assessing Neuroprotective Effects of Mitoquinone on H2O2-Induced Neurotoxicity in SH-SY5Y Neuroblastoma CellsSemantic proximity Read ↗

Harnessing the Therapeutic Potential of the Nrf2/Bach1 Signaling Pathway in Parkinson’s DiseaseSemantic proximity Read ↗

The role of Nrf2 signaling pathways in nerve damage repairSemantic proximity Read ↗

An Interactive Review on the Role of Tocotrienols in the Neurodegenerative DisordersSemantic proximity Read ↗

Combined neuroprotective potential of Levodopa and Resveratrol to ameliorates cognitive impairments in rotenone-induced Parkinson's disease via targeting TLR mediated neuroinflammationSemantic proximity Read ↗

Neuroprotective Effects of 1,2-Diarylpropane Type Phenylpropanoid Enantiomers from Red Raspberry against H2O2-Induced Oxidative Stress in Human Neuroblastoma SH-SY5Y CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.