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Article

LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease.

Nature cell biology - 1 Jan 2011

Griffiths Dean S, Li Juan, Dawson Mark A, Trotter Matthew W B, Cheng Yi-Han, Smith Aileen M, Mansfield William, Liu Pentao, Kouzarides Tony, Nichols Jennifer, Bannister Andrew J, Green Anthony R, Göttgens Berthold

Abstract excerpt

Activating mutations in the tyrosine kinase Janus kinase 2 (JAK2) cause myeloproliferative neoplasms, clonal blood stem cell disorders with a propensity for leukaemic transformation. Leukaemia inhibitory factor (LIF) signalling through the JAK-signal transducer and activator of transcription (STA...

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Source

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Identifiers

PMID: 21151131
DOI: 10.1038/ncb2135
PMCID: PMC3008749

Genes

JAK2
LIF
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21151131-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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