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Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures

6 May 2021

Abstract excerpt

Advances in the isolation and gene expression profiling of single hematopoietic stem cells (HSCs) have permitted in-depth resolution of their molecular program. However, long-term HSCs can only be isolated to near purity from adult mouse bone marrow, thereby precluding studies of their molecular program in different physiological states. Here, we describe a powerful 7-day HSC hibernation culture system that...

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PMID: 33961793
DOI: 10.1016/j.stemcr.2021.04.002

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