Article
Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice.
Aging - 1 Dec 2010
Dubrovsky Yulia V, Samsa William E, Kondratov Roman V
Abstract excerpt
Circadian clock is implicated in the regulation of aging. The transcription factor CLOCK, a core component of the circadian system, operates in complex with another circadian clock protein BMAL1. Recently it was demonstrated that BMAL1 deficiency results in premature aging in mice. Here we investigate the aging of mice deficient for CLOCK protein. Deficiency of the CLOCK protein significantly affects longevity:...
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