Article

An Aging-Susceptible Circadian Rhythm Controls Cutaneous Antiviral Immunity

2023-04-16

Abstract excerpt

<h4>ABSTRACT</h4> Aged skin is prone to viral infections, but the mechanisms responsible for this immunosenescent immune risk are unclear. We observed that aged murine and human skin expressed reduced antiviral proteins (AVPs) and circadian regulators including Bmal1 and Clock. Bmal1 and Clock were found to control rhythmic AVP expression in skin and such circadian-control of AVPs was diminished by disruption of...

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Literature Corpus work: d1b98eba-9cd2-557f-8114-adb4d6a96dba
DOI: 10.1101/2023.04.14.536934

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