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Article

An aging-susceptible circadian rhythm controls cutaneous antiviral immunity

19 Sept 2023

Abstract excerpt

Aged skin is prone to viral infections, but the mechanisms responsible for this immunosenescent immune risk are unclear. We observed that aged murine and human skin expressed reduced levels of antiviral proteins (AVPs) and circadian regulators, including Bmal1 and Clock. Bmal1 and Clock were found to control rhythmic AVP expression in skin, and such circadian control of AVPs was diminished by disruption of immune...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37725438
DOI: 10.1172/jci.insight.171548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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