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Article

Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer.

International journal of cancer - 15 Sept 2007

Guo MingZhou, House Michael G, Suzuki Hiromu, Ye Ying, Brock Malcolm V, Lu Fengmin, Liu Zhihua, Rustgi Anil K, Herman James G

Abstract excerpt

CDX2, a mammalian homologue of the homeobox gene 'caudal,' is expressed in gut epithelia and plays an important role in establishing the intestinal phenotype during development. Mice heterozygously disrupted for CDX2 develop disorganized polypoid hamartomas with glandular epithelium and stratified squamous metaplasia resembling foregut mucosa. Since no genetic disruptions of CDX2 have been reported to explain...

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Share to CDX2 Transcription Factor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasms, Squamous Cell

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Source

Identifiers

PMID: 17534889
DOI: 10.1002/ijc.22828

Genes

CDX2
MUC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer.PMID 17534889Read ↗

Silencing of CDX2 expression in colon cancer via a dominant repression pathway.Semantic proximity Read ↗

Altered expression of CDX2 in colorectal cancersSemantic proximity Read ↗

Cdx-2 expression in squamous and metaplastic columnar epithelia of the esophagus.Semantic proximity Read ↗

Cdx2 Controls Expression of the Protocadherin Mucdhl, an Inhibitor of Growth and β-Catenin Activity in Colon Cancer CellsSemantic proximity Read ↗

Relationship of CDX2 Loss with Molecular Features and Prognosis in Colorectal CancerSemantic proximity Read ↗

CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotypeSemantic proximity Read ↗

Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients.Semantic proximity Read ↗

The clinical perspectives of CDX2 expression in colorectal cancer: a qualitative systematic review.Semantic proximity Read ↗

Methylation of CDX2 as a Predictor in Poor Clinical Outcome of Patients with Colorectal CancerSemantic proximity Read ↗

CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling.Semantic proximity Read ↗

CDX2 expression in the intestinal-type gastric epithelial neoplasia: frequency and significance.Semantic proximity Read ↗

CDX2 does not suppress tumorigenicity in the human gastric cancer cell line MKN45.Semantic proximity Read ↗

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