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Article

CDX2 expression in the intestinal-type gastric epithelial neoplasia: frequency and significance.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2010

Park Do Youn, Srivastava Amitabh, Kim Gwang Ha, Mino-Kenudson Mari, Deshpande Vikram, Zukerberg Lawrence R, Song Geum Am, Lauwers Gregory Y

Abstract excerpt

CDX2 is an intestinal transcription factor responsible for regulating the proliferation and differentiation of intestinal epithelial cells. In gastric adenocarcinoma, CDX2 expression is known to be associated with limited invasiveness and intestinal phenotypes. The aims of this study were to analyze CDX2 expression in a series of well-characterized cases of gastric epithelial dysplasia, based on the morphologic...

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Source

Identifiers

PMID: 19820687
DOI: 10.1038/modpathol.2009.135

Genes

CDX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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CDX2 expression in the intestinal-type gastric epithelial neoplasia: frequency and significance.PMID 19820687Read ↗

CDX2 expression is increased in gastric cancers with less invasiveness and intestinal mucin phenotype.Semantic proximity Read ↗

Altered expression of CDX2 in colorectal cancersSemantic proximity Read ↗

Immunohistochemically detectable Cdx2 is present in intestinal phenotypic elements in early gastric cancers of both differentiated and undifferentiated types, with no correlation to non-neoplastic surrounding mucosa.Semantic proximity Read ↗

Divergent expression of MUC5AC, MUC6, MUC2, CD10, and CDX-2 in dysplasia and intramucosal adenocarcinomas with intestinal and foveolar morphology: is this evidence of distinct gastric and intestinal pathways to carcinogenesis in Barrett Esophagus?Semantic proximity Read ↗

Expression of the intestine-specific transcription factors, Cdx1 and Cdx2, correlates shift to an intestinal phenotype in gastric cancer cells.Semantic proximity Read ↗

The clinical perspectives of CDX2 expression in colorectal cancer: a qualitative systematic review.Semantic proximity Read ↗

Cdx2 transcription factor regulates claudin‐3 and claudin‐4 expression during intestinal differentiation of gastric carcinomaSemantic proximity Read ↗

Gastric Adenocarcinomas with CDX2 Induction Show Higher Frequency of TP53 and KMT2B Mutations and MYC Amplifications but Similar Survival Compared with Cancers with No CDX2 InductionSemantic proximity Read ↗

Transduced caudal‐type homeobox ( CDX ) 2/ CDX 1 can induce growth inhibition on CDX ‐deficient gastric cancer by rapid intestinal differentiationSemantic proximity Read ↗

Genetic alterations of the Cdx2 gene in gastric cancer.Semantic proximity Read ↗

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Sox2 expression is maintained while gastric phenotype is completely lost in Cdx2-induced intestinal metaplastic mucosa.Semantic proximity Read ↗

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