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DNA methylation in human gastric epithelial cells defines regional identity without restricting lineage plasticity

1 Dec 2022

Abstract excerpt

BACKGROUND: Epigenetic modifications in mammalian DNA are commonly manifested by DNA methylation. In the stomach, altered DNA methylation patterns have been observed following chronic Helicobacter pylori infections and in gastric cancer. In the context of epigenetic regulation, the regional nature of the stomach has been rarely considered in detail. RESULTS: Here, we establish gastric mucosa derived primary cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36585699
DOI: 10.1186/s13148-022-01406-4

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