Article
X-Chromosome inactivation in cloned mouse embryos.
Science (New York, N.Y.) - 24 Nov 2000
Eggan K, Akutsu H, Hochedlinger K, Rideout W, Yanagimachi R, Jaenisch R
Abstract excerpt
To study whether cloning resets the epigenetic differences between the two X chromosomes of a somatic female nucleus, we monitored X inactivation in cloned mouse embryos. Both X chromosomes were active during cleavage of cloned embryos, followed by random X inactivation in the embryo proper. In the trophectoderm (TE), X inactivation was nonrandom with the inactivated X of the somatic donor being chosen for...
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