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Article

Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti.

Hearing research - 1 May 2011

Pan Ning, Jahan Israt, Kersigo Jennifer, Kopecky Benjamin, Santi Peter, Johnson Shane, Schmitz Heather, Fritzsch Bernd

Abstract excerpt

Atonal homolog1 (Atoh1, formerly Math1) is a crucial bHLH transcription factor for inner ear hair cell differentiation. Its absence in embryos results in complete absence of mature hair cells at birth and its misexpression can generate extra hair cells. Thus Atoh1 may be both necessary and suffic...

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Source

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Identifiers

PMID: 21146598
DOI: 10.1016/j.heares.2010.12.002
PMCID: PMC3065550

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21146598-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti.PMID 21146598Read ↗

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