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Article

Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2.

Developmental cell - 14 Feb 2012

Ahmed Mohi, Wong Elaine Y M, Sun Jianbo, Xu Jinshu, Wang Feng, Xu Pin-Xian

Abstract excerpt

Inner-ear hair cell differentiation requires Atoh1 function, while Eya1, Six1, and Sox2 are coexpressed in sensory progenitors and mutations in these genes cause sensorineural hearing loss. However, how these genes are linked functionally and the transcriptional networks controlling hair cell induction remain unclear. Here, we show (1) that Eya1/Six1 are necessary for hair cell development, and their coexpression...

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Identifiers

PMID: 22340499
DOI: 10.1016/j.devcel.2011.12.006
PMCID: PMC3285434

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