Article
The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination.
Development (Cambridge, England) - 1 May 2002
Chen Ping, Johnson Jane E, Zoghbi Huda Y, Segil Neil
Abstract excerpt
During embryonic development of the inner ear, the sensory primordium that gives rise to the organ of Corti from within the cochlear epithelium is patterned into a stereotyped array of inner and outer sensory hair cells separated from each other by non-sensory supporting cells. Math1, a close homolog of the Drosophila proneural gene atonal, has been found to be both necessary and sufficient for the production of...
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