Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activity.

PloS one - 23 Feb 2010

Fritzsch Bernd, Dillard Miriam, Lavado Alfonso, Harvey Natasha L, Jahan Israt

Abstract excerpt

BACKGROUND: The homeobox gene Prox1 is required for lens, retina, pancreas, liver, and lymphatic vasculature development and is expressed in inner ear supporting cells and neurons. METHODOLOGY/PRINCIPAL FINDINGS: We have investigated the role of Prox1 in the developing mouse ear taking advantage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cochlea
Share to Ear, Inner
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelium

Share to Hair Cells, Auditory, Outer

Share to Microscopy, Confocal

Share to Microscopy, Electron, Transmission

Share to Vestibule, Labyrinth

Source

Open in PubMed Open full text

Identifiers

PMID: 20186345
DOI: 10.1371/journal.pone.0009377
PMCID: PMC2826422

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20186345-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activity.PMID 20186345Read ↗

Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear.Semantic proximity Read ↗

Lmx1a is required for segregation of sensory epithelia and normal ear histogenesis and morphogenesis.Semantic proximity Read ↗

The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear.Semantic proximity Read ↗

Lmx1a maintains proper neurogenic, sensory, and non-sensory domains in the mammalian inner ear.Semantic proximity Read ↗

FGFR1 is required for the development of the auditory sensory epithelium.Semantic proximity Read ↗

Foxg1 is required for proper separation and formation of sensory cristae during inner ear development.Semantic proximity Read ↗

Neurod1 regulates survival and formation of connections in mouse ear and brain.Semantic proximity Read ↗

Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial compartment of the developing cochleaSemantic proximity Read ↗

Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti.Semantic proximity Read ↗

Interaction with ectopic cochlear crista sensory epithelium disrupts basal cochlear sensory epithelium development in Lmx1a mutant mice.Semantic proximity Read ↗

The Notch ligand Jagged1 is required for inner ear sensory development.Semantic proximity Read ↗

Canonical Notch signaling plays an instructive role in auditory supporting cell development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.