DNA adduct formation in mouse testis by ethylating agents: a comparison with germ-cell mutagenesis.

doi:10.1016/0027-5107(90)90176-5

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Article

DNA adduct formation in mouse testis by ethylating agents: a comparison with germ-cell mutagenesis.

Mutation research - 1 Jul 1990

van Zeeland A A, de Groot A, Neuhäuser-Klaus A

Abstract excerpt

DNA adduct formation in various organs of mice was determined after i.p. injection with the ethylating agents N-ethyl-N-nitrosourea (ENU), ethyl methanesulfonate (EMS), and diethyl sulfate (DES). The potency of the 3 chemicals to react either at the O6 position of guanine or at the N-7 position o...

Topics

Alkylating Agents
Animals
Bone Marrow
DNA
Dose-Response Relationship, Drug
Ethyl Methanesulfonate
Ethylnitrosourea
Liver
Male
Mice
Mice, Inbred Strains
Mutagens
Mutation
Spermatozoa
Sulfuric Acid Esters
Sulfuric Acids
Testis

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