Article
Development of a nanoparticle that releases nucleic acids in response to a mitochondrial environment.
Mitochondrion - 1 May 2020
Yamada Yuma, Fukuda Yutaka, Sasaki Daisuke, Maruyama Minako, Harashima Hideyoshi
Abstract excerpt
The delivery of nucleic acids targeting mutant mtDNA represent a potential strategy for addressing a variety of mitochondria-related diseases. We previously developed a MITO-Porter, a nano carrier that is capable of delivering nanoparticles of nucleic acids to mitochondria of human cells. Here, we report on an investigation of a series of nanoparticles formed with various poly cationic peptides that can release...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.