Article

Development of carbamate modified PEI for delivery of a granzyme B inhibitor gene to protect against cytotoxic lymphocyte killing

2014-01-01

Abstract excerpt

Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells protect vertebrates by killing infected or transformed cells using granzyme B (GrB) to induce apoptosis. However, GrB-induced apoptosis causes inflammatory disease and allograft rejection and is an important disease target. The aim of this project is to prevent apoptosis of the target cells by delivering a plasmid encoding GrB inhibitor proteinase inhibi...

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Literature Corpus work: ab3dbe11-c6ae-5bd8-ae12-c5d69aac7bc1
DOI: 10.25560/23983

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