Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The serotonin transporter gene length polymorphism (5-HTTLPR) and life events: no evidence for an interaction effect on neuroticism and anxious depressive symptoms.

Twin research and human genetics : the official journal of the International Society for Twin Studies - 1 Dec 2010

Middeldorp Christel M, de Geus Eco J C, Willemsen Gonneke, Hottenga Jouke-Jan, Slagboom P Eline, Boomsma Dorret I

Abstract excerpt

The finding of a significant gene by environment interaction effect on depression of the serotonin transporter length polymorphism (5-HTTLPR) and the Number of experienced Life Events (NLE) was not replicated in two large meta-analyses (Munafo et al., 2009; Risch et al., 2009). These meta-analyse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety
Share to Depression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depressive Disorder

Share to Diseases in Twins

Share to Life Change Events

Share to Neurotic Disorders

Share to Serotonin Plasma Membrane Transport Proteins

Share to Siblings

Source

Identifiers

PMID: 21142930
DOI: 10.1375/twin.13.6.544

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21142930-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The serotonin transporter gene length polymorphism (5-HTTLPR) and life events: no evidence for an interaction effect on neuroticism and anxious depressive symptoms.PMID 21142930Read ↗

Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis.Semantic proximity Read ↗

The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression.Semantic proximity Read ↗

5-HTTLPR moderates effects of current life events on neuroticism: differential susceptibility to environmental influences.Semantic proximity Read ↗

Variations in 5-HTTLPR: relation to familiar risk of affective disorder, life events, neuroticism and cortisol.Semantic proximity Read ↗

Interaction between the 5-HTTLPR genotype, impact of stressful life events, and trait neuroticism on depressive symptoms in healthy volunteers.Semantic proximity Read ↗

Life events, first depression onset and the serotonin transporter gene.Semantic proximity Read ↗

Serotonin transporter genotype, salivary cortisol, neuroticism and life events: impact on subsequent psychopathology in healthy twins at high and low risk for affective disorder.Semantic proximity Read ↗

No interaction between the serotonin transporter polymorphism (5-HTTLPR) and childhood adversity or recent stressful life events on symptoms of depression: results from two community surveys.Semantic proximity Read ↗

The combined effects of the 5-HTTLPR and 5-HTR1A genes modulates the relationship between negative life events and major depressive disorder in a Chinese population.Semantic proximity Read ↗

Serotonin transporter gene and negative life change events are associated with depressive phenotype.Semantic proximity Read ↗

Stress-related negative affectivity and genetically altered serotonin transporter function: evidence of synergism in shaping risk of depression.Semantic proximity Read ↗

Stressful life events and the serotonin transporter gene (5-HTT) in recurrent clinical depression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.