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Article

Suppression of human immunodeficiency virus type-1 production by coexpression of catalytic-region-deleted N-myristoyltransferase mutants.

Biological & pharmaceutical bulletin - 1 Jan 2010

Takamune Nobutoki, Kuroe Tetsuya, Tanada Noriaki, Shoji Shozo, Misumi Shogo

Abstract excerpt

N-Myristoyltransferase (NMT) isozymes, i.e., NMT1 and NMT2, are essential host factors for the AIDS-causing human immunodeficiency virus type-1 (HIV-1), by which the viral proteins Pr55(gag) and Nef are N-myristoylated. N-Myristoylation is important for the membrane targeting of modified proteins. Since it is predicted that approximately 0.5% of all proteins in the human genome are N-myristoylated, selective...

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Source

Identifiers

PMID: 21139244
DOI: 10.1248/bpb.33.2018

Genes

NMT1
NMT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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