Article
Assembly-defective point mutants of the human immunodeficiency virus type 1 Gag precursor phenotypically expressed in recombinant baculovirus-infected cells.
Journal of virology - 1 May 1993
Hong S S, Boulanger P
Abstract excerpt
Two substitution mutants of the human immunodeficiency virus type 1 gag gene product were isolated after nitrous acid mutagenesis of a recombinant baculovirus expressing a non-N-myristylated, p6-deleted Gag precursor (Pr49). Both mutants failed to assemble intracellular Gag virus-like particles,...
Topics
- Acquired Immunodeficiency Syndrome
- Animals
- Baculoviridae
- Cells, Cultured
- Gene Products, gag
- Genetic Complementation Test
- Genotype
- HIV-1
- Moths
- Phenotype
- Point Mutation
- Protein Precursors
- Protein Processing, Post-Translational
- Virus Replication