Article
Genetic studies reveal that myristoylCoA:protein N-myristoyltransferase is an essential enzyme in Candida albicans.
Molecular microbiology - 1 Apr 1995
Weinberg R A, McWherter C A, Freeman S K, Wood D C, Gordon J I, Lee S C
Abstract excerpt
MyristoylCoA:protein N-myristoyltransferase (Nmt) catalyses the co-translational, covalent attachment of myristate (C14:0) to the amino-terminal glycine residue of a number of eukaryotic proteins involved in cellular growth and signal transduction. The NMT1 gene is essential for vegetative growth of Saccharomyces cerevisiae. Studies were carried out to determine if Nmt is also essential for vegetative growth of...
Topics
- Acyltransferases
- Amino Acid Sequence
- Animals
- Base Sequence
- Candida albicans
- Candidiasis
- Chromosome Mapping
- Heterozygote
- Mice
- Molecular Sequence Data
- Mutagenesis, Site-Directed