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Article

Cutting edge: critical role of intracellular osteopontin in antifungal innate immune responses.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2011

Inoue Makoto, Moriwaki Yasuhiro, Arikawa Tomohiro, Chen Yu-Hsun, Oh Young Joo, Oliver Timothy, Shinohara Mari L

Abstract excerpt

We found that absence of osteopontin (OPN) in immunocompromised Rag2(-/-) mice, which lack T and B cells, made the mice extremely susceptible to an opportunistic fungus Pneumocystis, although immunocompetent OPN-deficient mice could clear Pneumocystis as well as wild-type mice. OPN has been studied as an extracellular protein, and the role of an intracellular isoform of OPN (iOPN) is still largely unknown. In...

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Source

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Identifiers

PMID: 21135164
DOI: 10.4049/jimmunol.1002735
PMCID: PMC3538145

Genes

TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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