Elucidating the Pathogenesis of Spores from the Human Fungal Pathogen<i>Cryptococcus neoformans</i>

Abstract excerpt

Cryptococcus neoformans was first described as a human fungal pathogen more than a century ago. One aspect of the C. neoformans infectious life cycle that has been the subject of earnest debate is whether the spores are pathogenic. Despite much speculation, no direct evidence has been presented to resolve this outstanding question. We present evidence that C. neoformans spores are pathogenic in a mouse intranasal...

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