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Article

Osteopontin functionally activates dendritic cells and induces their differentiation toward a Th1-polarizing phenotype.

Blood - 1 Aug 2005

Renkl Andreas C, Wussler Julia, Ahrens Thomas, Thoma Käthe, Kon Shigeyuki, Uede Toshimitsu, Martin Stefan F, Simon Jan C, Weiss Johannes M

Abstract excerpt

Osteopontin (OPN) has been shown to have T helper 1 (Th1) cytokine functions in cell-mediated immunity. Deficiency of OPN is linked to a reduced Th1 immune response in autoimmunity, infectious disease, and delayed-type allergy. Dendritic cells (DCs) are central for the induction of T-cell-mediated immunity, when initially flexible DCs are instructed by priming signals and tissue-derived factors to adopt Th1, Th2,...

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Source

Identifiers

PMID: 15855273
DOI: 10.1182/blood-2004-08-3228

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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