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Piezo1 senses hyphae and initiates host defense against pathogenic fungi

1 Jun 2025

Abstract excerpt

Candida albicans metamorphoses from benign yeast to a rigid hyphal, becoming an opportunistic pathogen in immunocompromised patients. The process by which immune cells discern fungal transformations remains elusive. Here, we report that the mechanosensitive ion channel Piezo1 is indispensable for recognizing fungal hyphae and triggering antifungal innate immune responses. Hyphae-triggered Piezo1 activation...

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PMID: 40526468
DOI: 10.1016/j.celrep.2025.115839

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