Article
The combination of primary sclerosing cholangitis and CCR5-Δ32 in recipients is strongly associated with the development of nonanastomotic biliary strictures after liver transplantation.
Liver international : official journal of the International Association for the Study of the Liver - 1 Sept 2011
op den Dries Sanna, Buis Carlijn I, Adelmeijer Jelle, Van der Jagt Eric J, Haagsma Elizabeth B, Lisman Ton, Porte Robert J
Abstract excerpt
BACKGROUND: The role of the immune system in the pathogenesis of nonanastomotic biliary strictures (NAS) after orthotopic liver transplantation (OLT) is unclear. A loss-of-function mutation in the CC chemokine receptor 5 (CCR5-Δ32) leads to changes in the immune system, including impaired chemotaxis of regulatory T cells. AIM: To investigate the impact of the CCR5-Δ32 mutation on the development of NAS. METHODS:...
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