Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recipient's genetic R702W NOD2 variant is associated with an increased risk of bacterial infections after orthotopic liver transplantation.

PloS one - 1 Jan 2013

Janse Marcel, de Rooij Bert-Jan F, van Hoek Bart, van den Berg Arie P, Porte Robert J, Blokzijl Hans, Coenraad Minneke J, Hepkema Bouke G, Schaapherder Alexander F, Ringers Jan, Weersma Rinse K, Verspaget Hein W

Abstract excerpt

INTRODUCTION: Orthotopic liver transplantation (OLT) is accompanied by a significant postoperative infection risk. Immunosuppression to prevent rejection increases the susceptibility to infections, mainly by impairing the adaptive immune system. Genetic polymorphisms in the lectin complement pathway of the donor have recently been identified as important risk determinants of clinically significant bacterial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Infections
Share to Liver Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multivariate Analysis

Share to Nod2 Signaling Adaptor Protein

Share to Risk Factors

Share to Survival Analysis

Share to Tissue Donors

Share to Transplant Recipients

Source

Open in PubMed Open full text

Identifiers

PMID: 23977330
DOI: 10.1371/journal.pone.0072617
PMCID: PMC3747080

Genes

NOD2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recipient's genetic R702W NOD2 variant is associated with an increased risk of bacterial infections after orthotopic liver transplantation.PMID 23977330Read ↗

Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver transplantation.Semantic proximity Read ↗

Donor mannose-binding lectin deficiency increases the likelihood of clinically significant infection after liver transplantation.Semantic proximity Read ↗

C7 genotype of the donor may predict early bacterial infection after liver transplantation.Semantic proximity Read ↗

A non-interventional study of the genetic polymorphisms of NOD2 associated with increased mortality in non-alcoholic liver transplant patients.Semantic proximity Read ↗

Genetic variants of innate immune receptors and infections after liver transplantation.Semantic proximity Read ↗

Toll-like receptor 2 polymorphism and Gram-positive bacterial infections after liver transplantation.Semantic proximity Read ↗

Mannose-binding lectin and ficolin-2 gene polymorphisms predispose to cytomegalovirus (re)infection after orthotopic liver transplantation.Semantic proximity Read ↗

NOD2 gene variants are a risk factor for culture-positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis.Semantic proximity Read ↗

Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft-versus-host disease in patients who underwent an allogeneic transplantation.Semantic proximity Read ↗

Mannose-Binding Lectin-Deficient Donors Increase the Risk of Bacterial Infection and Bacterial Infection-Related Mortality After Liver Transplantation.Semantic proximity Read ↗

Homozygosity for the toll-like receptor 2 R753Q single-nucleotide polymorphism is a risk factor for cytomegalovirus disease after liver transplantation.Semantic proximity Read ↗

Mannose Binding Lectin Gene Polymorphisms Confer a Major Risk for Severe Infections After Liver TransplantationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.