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Article

Altered dosage of the Saccharomyces cerevisiae spindle pole body duplication gene, NDC1, leads to aneuploidy and polyploidy.

Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 1999

Chial H J, Giddings T H, Siewert E A, Hoyt M A, Winey M

Abstract excerpt

Saccharomyces cerevisiae cells are exquisitely sensitive to altered dosage of the spindle pole body duplication gene, NDC1. We show that the NDC1 locus is haploinsufficient because diploid yeast cells cannot survive with a single chromosomal copy of the NDC1 gene. Diploid cells with a single copy of NDC1 can survive by gaining an extra copy of the NDC1-containing chromosome. NDC1 haploinsufficiency is a dominant...

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Identifiers

PMID: 10468586
DOI: 10.1073/pnas.96.18.10200
PMCID: PMC17866

Genes

NDC1

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Altered dosage of the Saccharomyces cerevisiae spindle pole body duplication gene, NDC1, leads to aneuploidy and polyploidy.PMID 10468586Read ↗

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