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Article

Role of aspartate 143 in Escherichia coli tRNA-guanine transglycosylase: alteration of heterocyclic substrate specificity.

Biochemistry - 17 Jan 2006

Todorov Katherine Abold, Garcia George A

Abstract excerpt

tRNA-guanine transglycosylase (TGT) is a key enzyme involved in the post-transcriptional modification of certain tRNAs in their anticodon wobble positions with queuine. To maintain the correct Watson-Crick base pairing properties of the wobble base (and hence proper translation of the genetic code), TGT must recognize its heterocyclic substrate with high specificity. The X-ray crystal structure of a eubacterial...

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Identifiers

PMID: 16401090
DOI: 10.1021/bi051863d
PMCID: PMC2533737

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Source receipt: pubmed, retrieved 7 Sept 2026.

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